Ecstasy / E / MDMA

Drug Class:
Individual drugs:
Common Terms:
E, Ecstasy, MDMA, X, Molly, M
Standard Dose:
  • E is usually sold as a pressed pill. These pills come in various sizes and colours, usually stamped with different logos. "Pure MDMA" usually comes in a clear capsule.
  • Almost always swallowed as a pill or capsule.
  • 100-125mg (this varies widely when in pill form, and there maybe none present).
  • Can be snorted, injected or hooped (placed up the ass).
The Buzz:

For an excellent explanation of why E makes you feel the way it does, check out the slide show on the DanceSafe website.
  • When swallowed the effects come on within 20 - 40 minutes.
  • Initially little rushes of exhilaration until the peak high is felt 60 - 90 minutes after ingestion.
  • Increases in heart rate, blood pressure, body temperature and pupil dilation.
  • Suppression of appetite.
  • A sense of energy and alertness similar to, but not as euphoric as, amphetamine (speed).
  • A warm state of empathy and good feelings of self, and an understanding and acceptance of others.
  • An MDMA "high" lasts 3-5 hours, although many pills produce effects lasting longer, as they contain other substances.
Overdose and other negative effects:
  • In high doses, or when in a hot environment, ecstasy can lead to overheating.
  • In high doses ecstasy can lead to seizures, strokes, heart attacks or difficulty breathing (even in experienced users).
  • After-effects can include, or continued use can lead to, depression, agitation, anxiety, panic attacks and paranoia. Continued use can also lead to these symptoms.
  • Jaw clenching and teeth grinding can wear down your teeth or create cuts inside your mouth.
  • Temporary short term memory impairment (you forget what's going on or what conversations you are having).
  • Difficulty obtaining or maintaining an erection.
Dangerous Drug Combinations:
  • Mixing with other stimulants or depressants can increase your risk of negative effects.
  • Avoid taking E if you are on anti-depressant medication, especially MAOIs.
  • Be careful if you mix with Viagra®. If you do mix, take only ½ of each. If you get an erection that lasts more than 4 hours, go to a hospital emergency room.
HIV Medications & Ecstasy/MDMA
  • All Protease Inhibitors (PIs), as well as Elvitegravir /Cobicistat/TDF/FTC (Stribild) increase the amount of E/MDMA in your system. This is important to consider, as MDMA puts stress on your heart.
  • Idinavir (Crixivan) can increase chance of kidney stones due to dehydration.
  • Iopinavir/Ritonavir (Kaltra/Norvir) increases E/MDMA levels 5-10 times. Please avoid taking MDMA if you are on these medications.
  • Most MDMA is adultered with other substances, especially PMA/PMMA. It is recommended you test your MDMA to know what’s in it. You can order testing kits through TRIP.

Other Medications & Ecstasy/MDMA

Anti-depressants: can cause ‘serotonin syndrome’, with symptoms of agitation, sleeplessness, sweating, faster heart beat and muscle spasms. If this happens, seek medical help immediately. If you’re on anti-depressants get medical advice before taking E/MDMA or PMA/PMMA.